The accident occurred near the Laquecahue airfield in the Bio Bio region at approximately 1700 GMT.
Humberto Toro, the governor of Arauco said noting the region´s high winds, four passengers including a woman died after the plane had a troubled landing.
It was not clear if the pilot was killed .
The official told a Chilean television network, the aircraft, which was owned by a private company, was flying the Mocha Island-Tirua route about 720 kilometres (445 miles) south of Santiago.
Investigations into the incident´s cause are underway.