Nicknamed "the mother of all bombs", the GBU-43 Massive Ordnance Air Blast bomb was dropped last Thursday from an American MC-130 aircraft in the Achin district of Nangarhar province, bordering Pakistan.
Since then questions have surrounded the decision to use the weapon, which is one of the largest conventional bombs ever used in combat by the US military.
After arriving at the site the day after the strike , US troops fighting alongside Afghan forces have since left, but continue to conduct operations in the broader area, said US military spokesman Captain William Salvin.
"Access has been restricted but that's because it's a combat zone," he told Reuters. "We are in contact with the enemy."
Echoing initial estimates, Salvin said the US military has "high confidence" that no civilians were harmed.
"We were and we are kept in the dark and still we haven’t been able to go to the site," said one senior Afghan security official, who declined to be named because of the sensitivity of the issue.
"We are confused ourselves and we wonder what MOAB could have caused."
Information ‘black hole’
In meetings of the Afghan security council, some ministers told President Ashraf Ghani they feared the lack of information from the US side could be exploited by Daesh , which has continued radio broadcasts claiming none of its fighters were killed.
The attack was aimed at destroying an "extensive" complex of fortified tunnels and mines and not any particularly large concentration of fighters, he said.
"Our assessments are ongoing," Salvin said, noting that the strike appeared to have collapsed many tunnels, destroyed mines, and "reduced" several nearby structures.
For at least a month before the strike , the US military had broadcast radio messages warning of coming operations by American and Afghan troops in southern Nangarhar, and leaflets were dropped on areas affected by the operation, Salvin said.
"Afghan forces used to fire artillery, bombs were dropped by foreign aircraft, and even Daesh fired rockets at us and at the villagers," he added.
Residents in Achin district say that they knew of no civilians still living voluntarily in the areas near the Daesh stronghold, but it is still not clear if other non-combatants may have been involved.
"The people who'd normally be talking have fled, and there have been very few reports from inside Daesh territory," said Kate Clark, a senior researcher for the Afghan Analysts Network. "The jury's still out on many things with this strike ."
Some local residents suggested there may have been prisoners held in the tunnel complex, she added, but the area has been something of an information black hole since Daesh militants were first confirmed there in 2015.