Two other Chinese nationals were injured in Sunday's accident south of the capital Pyongyang, ministry spokesman Lu Kang told a regular press briefing.
"We are investigating the cause" of the accident, Lu said.
The ministry provided few details but China's state broadcaster CGTN earlier tweeted that more than 30 people died when a tour bus fell from a bridge in North Korea. The tweet was later deleted.
State broadcaster CCTV broadcast images of a large overturned vehicle with light rain falling on rescue vehicles and doctors attending to a patient.
China was informed about the accident on Sunday night, and its embassy personnel in Pyongyang rushed to the scene and are working to manage the situation, the foreign ministry said in a statement earlier.