Azhar Ali had hit an unbeaten 205 in Pakistan’s first innings, which was declared closed shortly after lunch.
Azhar Ali finished unbeaten on 205 after Wahab Riaz fell for one, caught and bowled by paceman Josh Hazlewood for his 100th test wicket.
Azhar’s double-century, the highest score by a Pakistan cricketer in Australia , put the tourists well in front but their chances of forcing a result have been reduced by the rain that disrupted the opening two days.
Hazlewood finished with 3-50, with fellow seamer Jackson Bird grabbing 3-113.
Earlier on rain hit days, the visitors had lost five very important wickets included Sami Aslam (9), Babar Azam (23), Younis Khan (21), Asad Shafiq (50) and skipper Misbah-ul-Haq (11).
Jackson Bird has taken 3 wickets whereas Josh Hazlewood bagged two and Nathan Lyon bagged a single wicket.
Pakistan captain Misbah-ul-Haq had won the toss and elected to bat in the second Test.
The Green shirts made one change, with right-arm paceman Sohail Khan replacing left-armer Rahat Ali while the hosts fielded the same squad who beat Pakistan by 39 runs at Gabba.
Australia squad for 1st Test: Steven Smith(c), David Warner , Jackson Bird, Peter Handscomb, Josh Hazlewood, Usman Khawaja , Nic Maddinson, Nathan Lyon, Matt Renshaw, Chadd Sayers, Mitchell Starc, Matthew Wade.