Sadequain was born on June 30, 1923 descending from a family of calligraphers. In late 1940s he joined the Progressive Writers and Artists Movement.
His true talent was discovered by Huseyn Shaheed Suhrawardy who brought Sadequain into the limelight. He received much praise for his calligraphic style, which is widely considered iconic by many critics of South Asian art.
Renowned for his work in Pakistan, Sadequain received national awards like the Tamgha-e-Imtiaz and the Presidential Medal of Honor. He was also recognized in art circles abroad, receiving the Paris Biennale Prize in 1961.